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KMID : 0861020080230010023
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Korea Journal of Herbology
2008 Volume.23 No. 1 p.23 ~ p.28
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Effects of Socheongryong-Tang on Immunoglobulin Production in Asthmatic Mice
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Jeong Sun
Cho Soo-Jin
Moon Kyoung-Il
kim Hyung-Woo
Kim Bu-Yeo
Cho Su-In
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Abstract
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Objectives: Socheongryong-Tang(小靑龍湯, SCRT), a herbal remedy, has been widely used to treat respiratory disease such as cough and asthma in Oriental countries. Recent years SCRT was known as anti-allergic agent. However, its therapeutic mechanisms including immunoglobuline such as IgE, IgG1, IgG2a productions are unclear.
Methods: We investigated the effects of SCRT on levels of antigen specific total antibody, IgE, IgG1,
IgG2a using ELISA method in serum from allergen-induced asthma mice.
Results: SCRT decreased level of antigen specific IgE significantly. And SCRT treated mice showed downward tendency of IgG1, a Th1 relative antibody, level. But, SCRT did not affect levels of antigen specific total antibody and IgG2a, a Th1 relative antibody.
Conclusions : we demonstrated the strong possibility of SCRT as a complementary or alternative drug to western drug also demonstrated that regulation of Th1/Th2 imbalance may be one of mechanism contributed to treatment for respiratory disease by SCRT.
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KEYWORD
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Socheongryong-Tang, IgE, IgG1, Herbal medicine, Asthma
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